Authors
RN Mcvicar, S Leibel, E Snyder, E Smith
Publication date
2024/5
Book
D106. CUTTING-EDGE SCIENCE ON BRONCHOPULMONARY DYSPLASIA
Pages
A7409-A7409
Publisher
American Thoracic Society
Description
RATIONALE
The human airway epithelium is vital in protecting the lungs against environmental threats. However, newborn infants are especially vulnerable to viral infections because their defense system is immature. Preterm infants with bronchopulmonary disease (BPD) are at a higher risk of severe respiratory syncytial virus (RSV) infections due to their limited ability to endogenously produce protective proteins in the airway and the naivety of their immune system. BPIFA1 is an airway surfactant that maintains airway homeostasis in mice and adult humans, but its role in neonatal human airway homeostasis remains unexplored. BPD can result from the lack of surfactant in the alveolar region of the lung but may also develop from reduced surfactant function in the airway. Here we investigate the gestational expression of BPIFA1 in the preterm lung and its function during RSV infections.
METHODS
Post-mortem …
Scholar articles
RN Mcvicar, S Leibel, E Snyder, E Smith - D106. CUTTING-EDGE SCIENCE ON …, 2024